B.S.E brings deeply impact to the Medical Device industrial. Not only the Europe Commission, but also Australia and even some Asian countries raised the bar for the medical device contains or made by animal source, which almost closed the door. The industrial has to think about to replace current animal sourced medical devices by new synthetic materials. Plain Catgut which has a very big market need to replace after banned in Europe, under this situation, Poly(glycolide-co-caprolactone)(PGA-PCL)(75%-25%) , short write as PGCL, was developed as has higher safety performance by the hydrolysis which much better than Catgut by Enzymolysis.